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Long-term consequences of crack use encompass: Impaired impulse control Malnutrition Withdrawal symptoms Memory loss Anhedonia (inability to feel pleasure) Hallucinations Cognitive impairment Constriction and hardening of blood vessels Sexual dysfunction Ulcers Suicidal or aggressive thoughts Anxiety Heart damage Slow-healing injuries Migraines Loss of motor skills Nerve damage Psychosis induced by cocaine Elevated risk of stroke Increased risk of heart attack Crack lung Depression Open sores near the eyes Harm to the soft tissues inside the nose, mouth, and throat Persistent respiratory issues Weight loss Tooth decay Bowel decay Seizures Self-harm tendencies Loss of smell Prolonged use of crack cocaine exposes users to the risk of infectious diseases such as HIV and hepatitis, often due to sharing drug paraphernalia and engaging in hazardous sexual activities

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To ensure consistency across measurement techniques of the two labs (from the current study and the comparison study), 40 blood samples were analyzed separately in each lab and we found very good inter-lab agreement for nicotine (r = 0.92)